Extensive cardiac involvement in laminopathies diagnosed in pediatric-aged patients: A single-center study.

doi:10.1016/j.hrthm.2025.01.034

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Article

Extensive cardiac involvement in laminopathies diagnosed in pediatric-aged patients: A single-center study.

Heart rhythm - 1 Dec 2025

Hayes Emily A, Foreman Kaitlyn, Wright Lydia K, Gajarski Robert J, Hor Kan, Garg Vidu, Cripe Linda H, Kertesz Naomi J, Nandi Deipanjan

Abstract excerpt

BACKGROUND: Pathogenic variations in lamin A/C (LMNA) result in a group of inherited conditions termed laminopathies. Cardiac manifestations of laminopathies include atrial and ventricular arrhythmias, atrioventricular conduction disorders, and cardiomyopathy, with or without skeletal muscle involvement. Because of rarity and previous cardiac characterization as adult onset, pediatric data are limited. OBJECTIVE:...

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Topics

Humans
Male
Female
Child
Child, Preschool
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lamin Type A

Laminopathies

Follow-Up Studies

Phenotype

Electrocardiography

Adolescent

Arrhythmias, Cardiac

Source

Open in PubMed

Identifiers

PMID: 39894135
DOI: 10.1016/j.hrthm.2025.01.034

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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