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Causal relationship between mental disorders and abdominal aortic aneurysm: Insights from the genetic perspective.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Mar 2025

Deng Ming-Gang, Chai Chen, Wang Kai, Zhao Zhi-Hui, Nie Jia-Qi, Liu Fang, Liang Yuehui, Liu Jiewei

Abstract excerpt

BACKGROUND: This study aims to investigate the genetic link between mental disorders-depression, schizophrenia (SCZ), and bipolar disorder (BIP)-and abdominal aortic aneurysm (AAA). METHODS: We first examined the genetic associations between AAA and mental disorders by analyzing global and local genetic correlations as well as shared genomic loci. Global genetic correlation was assessed using linkage...

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PMID: 39892846
DOI: 10.1016/j.pnpbp.2025.111277

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