Article
A comprehensive report of the clinical and mutational profiles of 30 Iranian malignant infantile osteopetrosis patients.
Molecular and cellular probes - 1 Feb 2025
Amirfiroozy Akbar, Naghinejad Maryam, Rezamand Azim, Farhangi Hamid, Golchehre Zahra, Jalali Hossein, Taheri Mohammad, Keramatipour Mohammad
Abstract excerpt
Osteopetrosis is a group of genetically and clinically diverse inherited disorders characterized by an increase in bone density. The main known cause is an abnormality in the development or function of osteoclasts. Hence, the process of bone resorption is impaired, resulting in: 1- a reduction in bone marrow volume and, subsequently, a decrement in the hematopoietic capacity of bone marrow, which leads to anemia...
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