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Article

An interracial Mendelian analysis revealed a link between lipid-lowering drugs and renal failure.

Lipids - 1 Jul 2025

Zhang Naidan, Ji Chaixia, Xie Baibing, Liu Yaoyang, Yuan Chengliang

Abstract excerpt

Lipid-lowering drugs have been used in clinics widely. It is unclear whether the drugs have an effect on renal failure. We chose high-density lipoprotein cholesterol (ieu-b-109), low-density lipoprotein cholesterol (ieu-a-300), triglyceride (ieu-b-111), and total cholesterol (ebi-a-GCST90038690) as exposures. SNPs near drug genes served as instrumental variables. Acute renal failure (ARF) and chronic renal...

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Share to Acute Kidney Injury
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39865353
DOI: 10.1002/lipd.12430

Genes

APOE
PPARG
NPC1L1
TNFSF12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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