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Article

APOE4, Alzheimer's and periodontal disease: A scoping review.

Ageing research reviews - 1 Mar 2025

Arévalo-Caro Catalina, Arce Retana Marianela, Losada Amaya Sergio, Arboleda Humberto, Gallart-Palau Xavier, Serra Aida

Abstract excerpt

OBJECTIVE: The ε4 allele of the apolipoprotein E gene (APOE4) is recognized as the primary genetic risk factor for Alzheimer's disease (AD) and has been associated with chronic inflammatory conditions, such as periodontal disease (PD). PD has been identified as having a potentiating effect that favors the development and progression of AD. This scoping review investigates the potential relationship between PD and...

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Identifiers

PMID: 39864561
DOI: 10.1016/j.arr.2024.102649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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