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Spatial localization of collagen hydroxylated proline site variation as an ancestral trait in the breast cancer microenvironment

23 Jan 2025

Abstract excerpt

Collagen stroma interactions within the extracellular microenvironment of breast tissue play a significant role in breast cancer, including risk, progression, and outcomes. Hydroxylation of proline (HYP) is a common post-translational modification directly linked to breast cancer survival and progression. Changes in HYP status lead to alterations in epithelial cell signaling, extracellular matrix remodeling, and...

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PMID: 39863086
DOI: 10.1016/j.matbio.2025.01.006

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