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Association between non-insulin-based insulin resistance indicators and frailty progression: a national cohort study and mendelian randomization analysis

22 Jan 2025

Abstract excerpt

BACKGROUND: Insulin resistance (IR) is linked to an increased risk of frailty, yet it remains unclear whether the non-insulin-based IR indicators are associated with frailty trajectories and physical function decline. It aimed to examine the associations of triglyceride-glucose (TyG) index, metabolic score for insulin resistance (METS-IR), estimated glucose disposal rate (eGDR) and with long-term...

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PMID: 39844267
DOI: 10.1186/s12933-025-02597-9

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