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Article

Association of Alzheimer's Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics.

Sports medicine (Auckland, N.Z.) - 1 Jun 2025

Dybing Kaitlyn M, McAllister Thomas W, Wu Yu-Chien, McDonald Brenna C, Broglio Steven P, Mihalik Jason P, Guskiewicz Kevin M, Goldman Joshua T, Jackson Jonathan C, Saykin Andrew J, Risacher Shannon L, Nudelman Kelly N H

Abstract excerpt

BACKGROUND: Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk genes associate with concussion severity/recovery, and the limited findings are mixed. OBJECTIVE: We used AD polygenic risk scores (PRS) and...

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Identifiers

PMID: 39821585
DOI: 10.1007/s40279-024-02150-w
PMCID: PMC12152024

Genes

APOE

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