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Article

Assessing the causal effect of genetically predicted metabolites and metabolic pathways on vitiligo: Evidence from Mendelian randomization and animal experiments.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2025

Li Guanglu, Qu Baoquan, Zheng Tao, Cheng Yi, Li Ping, Liu Zunjing, Zhao Jingxia

Abstract excerpt

Vitiligo is a common chronic skin depigmentation disorder that seriously decreases the patients' overall quality of life. Human blood metabolites could contribute to unraveling the underlying biological mechanisms of vitiligo. We used GWAS summary statistics to assess the causal association between genetically predicted 1400 serum metabolites and vitiligo risk by Mendelian randomization (MR). Then, after...

Read the complete abstract on PubMed

Topics

Animals
Vitiligo
Mendelian Randomization Analysis
Mice
Humans
Metabolomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Metabolic Networks and Pathways

Genome-Wide Association Study

Disease Models, Animal

Polymorphism, Single Nucleotide

Metabolome

Source

Identifiers

PMID: 39818343
DOI: 10.1016/j.jsbmb.2025.106677

Provenance

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