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G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication

15 Jan 2025

Abstract excerpt

Future pandemic threats may be caused by novel coronaviruses and influenza A viruses. Here we show that when directly added to a cell culture, 12mer guanine RNA (G12) and its phosphorothioate-linked derivatives (G12(S)), rapidly entered cytoplasm and suppressed the propagation of human coronaviruses and influenza A viruses to between 1/100 and nearly 1/1000 of normal virus infectivity without cellular toxicity...

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PMID: 39815031
DOI: 10.1038/s42003-024-07351-7

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