Transcriptomic profiling of chronic hand eczema skin reveals shared immune pathways and molecular drivers across subtypes

Abstract excerpt

BACKGROUND: Chronic hand eczema (CHE) is a common skin disease with different subtypes, but knowledge of the molecular patterns associated with each subtype is limited. OBJECTIVE: We sought to characterize the CHE transcriptome across subtypes. METHODS: Using RNA sequencing, we studied the transcriptome of 220 full-thickness skin biopsy samples collected from palms, dorsa, and arms from 96 patients with CHE...

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