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Article

Transgenerational associations between newborn metabolic profiles and bronchopulmonary dysplasia in neonates born to mothers with an obese phenotype.

Scientific reports - 7 Jan 2025

Reiss Jonathan D, Yang Wei, Chang Alan L, Long Jonathan Z, Marić Ivana, Profit Jochen, Sylvester Karl G, Stevenson David K, Aghaeepour Nima, Shaw Gary M

Abstract excerpt

Maternal obesity increases risk for bronchopulmonary dysplasia (BPD) by up to 42%. Identifying metabolic features that may contribute to the association between maternal pre-pregnancy body mass index (BMI) and BPD is critical in defining the molecular relationship between these conditions. We investigated the association between maternal obesity and BPD using newborn screen metabolites as an explanatory variable....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39774255
DOI: 10.1038/s41598-025-85252-3
PMCID: PMC11707363

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