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Article

Phenotypic diversity of CTCs and tdEVs in liquid biopsies of tumour-draining veins is linked to poor prognosis in colorectal cancer.

Journal of experimental & clinical cancer research : CR - 8 Jan 2025

Cieslik Stefan A, Zafra Andrés G, Driemel Christiane, Sudarsanam Monica, Cieslik Jan-Philipp, Flügen Georg, Dizdar Levent, Krieg Andreas, Vaghiri Sascha, Ashmawy Hany, Fung Stephen, Wilms Miriam, Terstappen Leon W M M, Nanou Afroditi, Neubauer Hans, Rahbari Nuh N, Knoefel Wolfram T, Stoecklein Nikolas H, Neves Rui P L

Abstract excerpt

BACKGROUND: Circulating tumour cells (CTCs) and tumour-derived extracellular vesicles (tdEVs) have great potential for monitoring therapy response and early detection of tumour relapse, facilitating personalized adjuvant therapeutic strategies. However, their low abundance in peripheral blood limits their informative value. In this study, we explored the presence of CTCs and tdEVs collected intraoperatively from...

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PMID: 39773651
DOI: 10.1186/s13046-024-03259-6

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