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Genetic Variant Analyses Identify Novel Candidate Autism Risk Genes from a Highly Consanguineous Cohort of 104 Families from Oman.

International journal of molecular sciences - 21 Dec 2024

Gupta Vijay, Ben-Mahmoud Afif, Idris Ahmed B, Hottenga Jouke-Jan, Habbab Wesal, Alsayegh Abeer, Kim Hyung-Goo, Al-Mamari Watfa, Stanton Lawrence W

Abstract excerpt

Deficits in social communication, restricted interests, and repetitive behaviours are hallmarks of autism spectrum disorder (ASD). Despite high genetic heritability, the majority of clinically diagnosed ASD cases have unknown genetic origins. We performed genome sequencing on mothers, fathers, and affected individuals from 104 families with ASD in Oman, a Middle Eastern country underrepresented in international...

Topics

Humans
Oman
Male
Female
Consanguinity
Genetic Predisposition to Disease
Autism Spectrum Disorder
Child
Pedigree
Cohort Studies
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Child, Preschool

Genetic Variation

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PMID: 39769462
DOI: 10.3390/ijms252413700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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