PreTKcat: A pre-trained representation learning and machine learning framework for predicting enzyme turnover number.

Abstract excerpt

The enzyme turnover number (kcat) is crucial for understanding enzyme kinetics and optimizing biotechnological processes. However, experimentally measured kcat values are limited due to the high cost and labor intensity of wet-lab measurements, necessitating robust computational methods. To address this issue, we propose PreTKcat, a framework that integrates pre-trained representation learning and machine...

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