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SARS‐CoV‐2 Productively Infects Human Hepatocytes and Induces Cell Death

1 Jan 2025

Abstract excerpt

SARS-CoV-2 infection is accompanied by elevated liver enzymes, and patients with pre-existing liver conditions experience more severe disease. While it was known that SARS-CoV-2 infects human hepatocytes, our study determines the mechanism of infection, demonstrates viral replication and spread, and highlights direct hepatocyte damage. Viral replication was readily detectable upon infection of primary human...

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PMID: 39760326
DOI: 10.1002/jmv.70156

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