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Article

Association of endothelial nitric oxide synthase (NOS3) rs2070744 variant with advanced retinopathy of prematurity: a case-control study and meta-analysis.

Scientific reports - 2 Jan 2025

Choręziak-Michalak Aneta, Szpecht Dawid, Woźniak Tomasz, Chmielarz-Czarnocińska Anna, Gazińska Patrycja, Gotz-Więckowska Anna, Strauss Ewa

Abstract excerpt

Despite advances in neonatal and ophthalmological care, retinopathy of prematurity (ROP) continues to be a leading cause of childhood blindness worldwide. Investigating gene variants associated with vascular responses in ROP may provide valuable insights into its pathogenesis and identify risk or protective factors. Nitric oxide (NO) and endothelin-1 (ET-1) play roles in vascular regulation, influencing processes...

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Identifiers

PMID: 39747280
DOI: 10.1038/s41598-024-83305-7
PMCID: PMC11696690

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