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Same-day molecular testing for targetable mutations in solid tumor cytopathology-The next frontier of the rapid on-site evaluation.

Cancer cytopathology - 1 Jan 2025

Iorgulescu J Bryan, Yang Richard Kenneth, Roy-Chowdhuri Sinchita, Sura Gloria Hopkins

Abstract excerpt

INTRODUCTION: This study aimed to assess the feasibility of implementing the Idylla system, an ultra-rapid, cartridge-based assay, as an extension of rapid on-site evaluation (ROSE) in cytology. The authors conducted a pilot validation study on specimens from non-small cell lung carcinoma, thyroid carcinoma, and melanoma, evaluating four assays designed to detect alterations in KRAS, EGFR, BRAF, gene fusions, and...

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Identifiers

PMID: 39746874
DOI: 10.1002/cncy.22930

Genes

BRAF
EGFR
KRAS
ALK
MET
NTRK1
RET
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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