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Article

Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study.

Molecular psychiatry - 1 Jun 2025

Di Yazheng, Rahmani Elior, Mefford Joel, Wang Jinhan, Ravi Vijay, Gorla Aditya, Alwan Abeer, Kendler Kenneth S, Zhu Tingshao, Flint Jonathan

Abstract excerpt

Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in a multisite...

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PMID: 39741179
DOI: 10.1038/s41380-024-02877-y
PMCID: PMC12092242

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