SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations.

doi:10.1038/s41467-024-55147-4

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Article

SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations.

Nature communications - 30 Dec 2024

Yang Meng-Yuan, Zhong Jia-Dong, Li Xin, Tian Geng, Bai Wei-Yang, Fang Yi-Hu, Qiu Mo-Chang, Yuan Cheng-Da, Yu Chun-Fu, Li Nan, Yang Ji-Jian, Liu Yu-Heng, Yu Shi-Hui, Zhao Wei-Wei, Liu Jun-Quan, Sun Yi, Cong Pei-Kuan, Khederzadeh Saber, Zhao Pian-Pian, Qian Yu, Guan Peng-Lin, Gu Jia-Xuan, Gai Si-Rui, Yi Xiang-Jiao, Tao Jian-Guo, Chen Xiang, Miao Mao-Mao, Lei Lan-Xin, Xu Lin, Xie Shu-Yang, Li Jin-Chen, Guo Ji-Feng, Karasik David, Yang Liu, Tang Bei-Sha, Huang Fei, Zheng Hou-Feng

Abstract excerpt

Limited whole genome sequencing (WGS) studies in Asian populations result in a lack of representative reference panels, thus hindering the discovery of ancestry-specific variants. Here, we present the South and East Asian reference Database (SEAD) panel ( https://imputationserver.westlake.edu.cn/ ), which integrates WGS data for 11,067 individuals from various sources across 17 Asian countries. The SEAD panel,...

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PMID: 39738056
DOI: 10.1038/s41467-024-55147-4
PMCID: PMC11686012

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