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Article

Phocaeicola vulgatus shapes the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile.

Cell host & microbe - 8 Jan 2025

Sulaiman Jordy Evan, Thompson Jaron, Cheung Pak Lun Kevin, Qian Yili, Mill Jericha, James Isabella, Im Hanhyeok, Vivas Eugenio I, Simcox Judith, Venturelli Ophelia S

Abstract excerpt

Clostridioides difficile can transiently or persistently colonize the human gut, posing a risk for infections. This colonization is influenced by complex molecular and ecological interactions with the human gut microbiota. By investigating C. difficile dynamics in human gut communities over hundreds of generations, we show patterns of stable coexistence, instability, or competitive exclusion. Lowering...

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Topics

Clostridioides difficile
Animals
Humans
Mice
Clostridium Infections
Gastrointestinal Microbiome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Symbiosis

Adaptation, Physiological

Mutation

Source

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Identifiers

PMID: 39730002
DOI: 10.1016/j.chom.2024.12.001
PMCID: PMC11852276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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