Article
Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus.
Frontiers in immunology - 1 Jan 2024
Cao Jianye, Du Tiantao, Li Jian, Chen Baiyu, Xie Xianting, Zhang Guoshu, Feng Jia, Xu Tao
Abstract excerpt
Background: Lichen planus (LP), an autoimmune disorder, remains incompletely understood in terms of its etiological mechanisms. This study aims to elucidate causal relationships among immune cell populations, plasma metabolites, and lichen planus using Mendelian randomization (MR) techniques. Methods: Employing a two-sample, two-step MR approach, with single nucleotide polymorphisms (SNP) serving as genetic...
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