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The Significance of Detecting an Unusual Myeloblast Immunophenotype in a Presumptive Clinical Diagnosis of Myelodysplastic Syndromes.

Archives of pathology & laboratory medicine - 1 Aug 2025

Sameeta Fnu, Wang Wei, Jelloul Fatima Zahra, Nwogbo Okechukwu V, Thakral Beenu, Xu Jie, Li Shaoying, Ok Chi Young, Tang Guilin, Jia Fuli, Medeiros L Jeffrey, Loghavi Sanam, Jorgensen Jeffrey L, Wang Sa A

Abstract excerpt

CONTEXT.—: Blasts in myelodysplastic syndromes (MDSs) typically have a primitive myeloid immunophenotype (CD34+CD117+CD13+CD33+HLA-DR+). On rare occasions, blasts were found to be CD34 negative or minimally expressed in a presumptive MDS. OBJECTIVE.—: To investigate the occurrence of these cases, and to examine any unique molecular genetic features, and clinical relevance. DESIGN.—: More than 2000 flow cytometry...

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Share to Antigens, CD34
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39711284
DOI: 10.5858/arpa.2024-0228-OA

Genes

CD34
NPM1
TP53
CD33
KMT2A
MLF1

Provenance

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