Article
The Significance of Detecting an Unusual Myeloblast Immunophenotype in a Presumptive Clinical Diagnosis of Myelodysplastic Syndromes.
Archives of pathology & laboratory medicine - 1 Aug 2025
Sameeta Fnu, Wang Wei, Jelloul Fatima Zahra, Nwogbo Okechukwu V, Thakral Beenu, Xu Jie, Li Shaoying, Ok Chi Young, Tang Guilin, Jia Fuli, Medeiros L Jeffrey, Loghavi Sanam, Jorgensen Jeffrey L, Wang Sa A
Abstract excerpt
CONTEXT.—: Blasts in myelodysplastic syndromes (MDSs) typically have a primitive myeloid immunophenotype (CD34+CD117+CD13+CD33+HLA-DR+). On rare occasions, blasts were found to be CD34 negative or minimally expressed in a presumptive MDS. OBJECTIVE.—: To investigate the occurrence of these cases, and to examine any unique molecular genetic features, and clinical relevance. DESIGN.—: More than 2000 flow cytometry...
Topics
- Humans
- Myelodysplastic Syndromes
- Nucleophosmin
- Immunophenotyping
- Male
- Aged
- Female
- Middle Aged
- Retrospective Studies
- Aged, 80 and over