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CHMP2B promotes CHMP7 mediated nuclear pore complex injury in sporadic ALS

21 Dec 2024

Abstract excerpt

Alterations to the composition and function of neuronal nuclear pore complexes (NPCs) have been documented in multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS). Moreover, recent work has suggested that injury to the NPC can at least in part contribute to TDP-43 loss of function and mislocalization, a pathological hallmark of ALS and related neurodegenerative diseases. Collectively,...

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PMID: 39709457
DOI: 10.1186/s40478-024-01916-7

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