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Article

Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk.

JNCI cancer spectrum - 3 Jan 2025

MacInnis Robert J, Jenkins Mark A, Milne Roger L, John Esther M, Daly Mary B, Andrulis Irene L, Colonna Sarah V, Phillips Kelly-Anne, Le Marchand Loic, Newcomb Polly A, Phipps Amanda I, Schmit Stephanie L, Macrae Finlay A, Buchanan Daniel D, Gallinger Steven, Pai Rish K, Samadder Niloy J, Giles Graham G, Southey Melissa C, Hopper John L, Terry Mary Beth

Abstract excerpt

Menopausal users of hormone replacement therapy (HRT) are at increased breast cancer risk and decreased colorectal cancer (CRC) risk compared with individuals who have never used HRT, but these opposing associations may differ by familial risk of breast cancer and CRC. We harmonized data from 3 cohorts and generated separate breast cancer and CRC familial risk scores based on cancer family history. We defined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39673461
DOI: 10.1093/jncics/pkae121
PMCID: PMC11700558

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