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Exogenous binding immunoglobulin protein (BiP) enhance immune regulatory phenotype in ex-vivo Mtb infected PBMCs stratified based on QuantiFERON response.

Cytokine - 1 Feb 2025

Motaung Bongani, Snyders Candice, Malherbe Stephanus, Gutschmidt Andrea, van Rensburg Ilana, Loxton Andre G

Abstract excerpt

Even though anti-tuberculosis (TB) treatment is readily available, Mycobacterium tuberculosis (Mtb) infection continues to be a global threat with a high death rate recorded from a single infectious agent. This highlights the significance of developing new strategies to curb the growing Mtb infection cases. Host-directed therapies (HDT) offer a promising approach that includes both drug discovery and drug...

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PMID: 39671882
DOI: 10.1016/j.cyto.2024.156832

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