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Article

Onset and Progression of Disease in Nonhuman Primates With PDE6C Cone Disorder.

Investigative ophthalmology & visual science - 2 Dec 2024

Ardon Monica, Nguyen Lily, Chen Rui, Rogers Jeffrey, Stout Tim, Thomasy Sara, Moshiri Ala

Abstract excerpt

Purpose: The California National Primate Research Center contains a colony of rhesus macaques with a homozygous missense mutation in PDE6C (R565Q) which causes a cone disorder similar to PDE6C achromatopsia in humans. The purposes of this study are to characterize the phenotype in PDE6C macaques in detail to determine the onset of the cone phenotype, the degree to which the phenotype progresses, if heterozygote...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39641747
DOI: 10.1167/iovs.65.14.16
PMCID: PMC11629912

Genes

PDE6C
ERG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Onset and Progression of Disease in Nonhuman Primates With PDE6C Cone Disorder.PMID 39641747Read ↗

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