Article
Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile.
Lab animal - 1 Jan 2025
Knuth Megan M, Campos Carolina Vieira, Smith Kirsten, Hutchins Elizabeth K, Lewis Shantae, York Mary, Coghill Lyndon M, Franklin Craig, MacFarlane Amanda J, Ericsson Aaron C, Magnuson Terry, Ideraabdullah Folami
Abstract excerpt
Standard chow diets influence reproducibility in animal model experiments because chows have different nutrient compositions, which can independently influence phenotypes. However, there is little evidence of the role of timing in the extent of variability caused by chow exposure. Here we measured the impact of different diets (5V5M, 5V0G, 2920X and 5058) and timing of exposure (adult exposure (AE), lifetime...
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