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Exploring the immune evasion of SARS-CoV-2 variant harboring E484K by molecular dynamics simulations

8 Sept 2021

Abstract excerpt

Although the current coronavirus disease 2019 (COVID-19) vaccines have been used worldwide to halt spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the emergence of new SARS-CoV-2 variants with E484K mutation shows significant resistance to the neutralization of vaccine sera. To better understand the resistant mechanism, we calculated the binding affinities of 26 antibodies to wild-type...

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PMID: 34553217
DOI: 10.1093/bib/bbab383

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