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Article

LIMO-GCN: a linear model-integrated graph convolutional network for predicting Alzheimer disease genes.

Briefings in bioinformatics - 22 Nov 2024

Lin Cui-Xiang, Li Hong-Dong, Wang Jianxin

Abstract excerpt

Alzheimer's disease (AD) is a complex disease with its genetic etiology not fully understood. Gene network-based methods have been proven promising in predicting AD genes. However, existing approaches are limited in their ability to model the nonlinear relationship between networks and disease genes, because (i) any data can be theoretically decomposed into the sum of a linear part and a nonlinear part, (ii) the...

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PMID: 39592152
DOI: 10.1093/bib/bbae611
PMCID: PMC11596108

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