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Article

Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium

26 Nov 2024

Abstract excerpt

Purpose: Oxidative stress in the retinal pigmented epithelium (RPE) has been implicated in age-related macular degeneration by impacting endocytic trafficking, including the formation, content, and secretion of extracellular vesicles (EVs). Using our model of polarized primary porcine RPE (pRPE) cells under chronic subtoxic oxidative stress, we tested the hypothesis that RPE miRNAs packaged into EVs are secreted...

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PMID: 39589346
DOI: 10.1167/iovs.65.13.57

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