Article
Role of Hog1-mediated stress tolerance in biofilm formation by the pathogenic fungus Trichosporon asahii.
Scientific reports - 20 Nov 2024
Matsumoto Yasuhiko, Nakayama Mei, Shimizu Yuta, Koganesawa Sachi, Kanai Hiromi, Sugiyama Yu, Kurakado Sanae, Sugita Takashi
Abstract excerpt
Trichosporon asahii, a dimorphic fungus, causes bloodstream infections in immunocompromised patients with neutropenia. Biofilms are formed on the surfaces of medical devices such as catheters as T. asahii transitions morphologically from yeast to hyphae in the host environment. Oxidative stress tolerance and morphological changes of T. asahii are regulated by Hog1, a mitogen-activated protein kinase. The role of...
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