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Article

Development of a new genotype-phenotype linked antibody screening system.

eLife - 19 Nov 2024

Watanabe Takashi, Hata Hikaru, Mochizuki Yoshiki, Yokoyama Fumie, Hasegawa Tomoko, Kumar Naveen, Kurosaki Tomohiro, Ohara Osamu, Fukuyama Hidehiro

Abstract excerpt

Antibodies are powerful tools for the therapy and diagnosis of various diseases. In addition to conventional hybridoma-based screening, recombinant antibody-based screening has become a common choice; however, its application is hampered by two factors: (1) screening starts after Ig gene cloning and recombinant antibody production only, and (2) the antibody is composed of paired chains, heavy and light, commonly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39558690
DOI: 10.7554/eLife.95346
PMCID: PMC11575895

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