Article
The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism.
Investigative ophthalmology & visual science - 4 Nov 2024
Xu Zihe, Tan Jit Kai, Vetrivel Krishnika, Jiang Xiaofan, Leo Shaun M, Bhatti Taha, Tariq Ambreen, Webster Andrew R, Robson Anthony G, Hammond Christopher J, Hysi Pirro G, Mahroo Omar A
Abstract excerpt
Purpose: One of the strongest genetic associations with myopia is near the GJD2 gene. Recently, this locus was associated with cone-driven electroretinograms (ERGs), with findings highlighting OFF pathway signals specifically. The ERG i-wave is thought to originate in retinal OFF pathways. We explored this component and tested the hypothesis that it would be associated with the myopia risk locus. Methods:...
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