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Article

Electrophysiological ON and OFF Responses in Autosomal Dominant Optic Atrophy.

Investigative ophthalmology & visual science - 1 Dec 2015

Morny Enyam Komla A, Margrain Tom H, Binns Alison M, Votruba Marcela

Abstract excerpt

PURPOSE: To assess the effect of autosomal dominant optic atrophy (ADOA) on ON and OFF retinal ganglion cell (RGC) function by evaluating the ON and OFF components of the photopic negative response (PhNR). METHODS: Twelve participants from six families with OPA1 ADOA and 16 age-matched controls were recruited. Electrophysiological assessment involved pattern ERGs (PERGs), focal (20°) and full-field long-duration...

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Source

Identifiers

PMID: 26624494
DOI: 10.1167/iovs.15-17951

Genes

ERG
OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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