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Article

Impact of Continuous Ofatumumab Exposure During Pregnancy in Multiple Sclerosis

7 Nov 2024

Abstract excerpt

Objectives: Anti-CD20 therapies are highly effective treatment options for patients with multiple sclerosis (MS), an inflammatory disorder of the CNS commonly affecting women of childbearing age. Anti-CD20 therapies are however unlicensed for use in pregnancy. Belonging to the IgG1 family, anti-CD20 monoclonal antibodies are likely to cross the placenta, especially after the 20th week of gestation. Our objective...

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PMID: 39524100
DOI: 10.1212/cpj.0000000000200410

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