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Article

Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma.

Scientific reports - 7 Nov 2024

Che Zhifei, Jin Wenyi, Wu Yaoxi, Li Haoyong, Liang Peiyu

Abstract excerpt

The crosstalk between cuproptosis and the tumor immune microenvironment (TIME) is vital during clear cell renal cell carcinoma (ccRCC) malignant progression. However, the underlying molecular mechanisms regulate this cross-talk remain elusive. Through tailored machine learning, we analyze clinical ccRCC data from The Cancer Genome Atlas (TCGA) to explore the critical factors that regulate the interaction among...

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Identifiers

PMID: 39511359
DOI: 10.1038/s41598-024-78713-8
PMCID: PMC11543667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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