Article
A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2.
Signal transduction and targeted therapy - 6 Nov 2024
An Ran, Yang Hao, Tang Cong, Li Qianqian, Huang Qing, Wang Haixuan, Wang Junbin, Zhou Yanan, Yang Yun, Chen Hongyu, Yu Wenhai, Li Bai, Wu Daoju, Zhang Yong, Luo Fangyu, Quan Wenqi, Xu Jingwen, Lin Dongdong, Liang Xiaoming, Yan Yuhuan, Yuan Longhai, Du Xuena, Yuan Yuxia, Li Yanwen, Sun Qiangming, Wang Youchun, Lu Shuaiyao
Abstract excerpt
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge and evade immunity, resulting in breakthrough infections in vaccinated populations. There is an urgent need for the development of vaccines with broad protective effects. In this study, we selected hotspot mutations in the receptor-binding domain (RBD) that contribute to immune escape properties and integrated them into...
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