Tumor-intrinsic chemosensitivity assessed by KELIM and prognosis by BRCA status in patients with advanced ovarian carcinomas.

doi:10.1136/ijgc-2024-005815

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Article

Tumor-intrinsic chemosensitivity assessed by KELIM and prognosis by BRCA status in patients with advanced ovarian carcinomas.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 May 2025

Becker Ondine, Durand Alice, Chevrier Marion, Collet Laetitia, Gladieff Laurence, Joly Florence, Sauterey Baptiste, Pomel Christophe, Costaz Hélène, Pautier Patricia, Guillemet Cécile, Rouge Thibault de la Motte, Sabatier Renaud, Classe Jean-Marc, Petit Thierry, Leblanc Eric, Marchal Frédéric, Colombo Pierre-Emmanuel, Barranger Emmanuel, Savoye Aude-Marie, Bosquet Lise, Ray-Coquard Isabelle, Carton Matthieu, Colomban Oliver, You Benoit, Rodrigues Manuel

Abstract excerpt

OBJECTIVE: Treatment of high-grade serous ovarian carcinomas relies on surgery and chemotherapy, potentially followed by bevacizumab and/or poly (ADP-ribose) polymerase inhibitors (PARPi). The modeled CA-125 ELIMination rate constant K (KELIM) is a pragmatic indicator of tumor primary chemosensitivity. Although it is well established that BRCA mutations are associated with platinum sensitivity, the relationship...

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PMID: 39481880
DOI: 10.1136/ijgc-2024-005815

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