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Article

Association of ATM and ARID1A in gastric carcinoma.

Pathology, research and practice - 1 Nov 2024

Hwang Inwoo, Lee Somin, Kim Yuyeon, Kim Deok Geun, Kang So Young, Ahn Soomin, Lee Jeeyun, Kim Kyoung-Mee

Abstract excerpt

BACKGROUND: The ataxia telangiectasia mutated (ATM) gene is involved in the repair of double-stranded DNA breaks and a component of the DNA damage repair pathway. Tumors with mutations or low expression of both ARID1A and ATM exhibit increased numbers of tumor-infiltrating lymphocytes and a favorable prognosis. However, the relationship between ATM and ARID1A in gastric carcinoma (GC) is unclear. METHODS: We used...

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PMID: 39476606
DOI: 10.1016/j.prp.2024.155664

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