Article
Mutations of PDS5 genes enhance TAD-like domain formation Arabidopsis thaliana.
Nature communications - 29 Oct 2024
Göbel Anna-Maria, Zhou Sida, Wang Zhidan, Tzourtzou Sofia, Himmelbach Axel, Zheng Shiwei, Pradillo Mónica, Liu Chang, Jiang Hua
Abstract excerpt
In eukaryotes, topologically associating domains (TADs) organize the genome into functional compartments. While TAD-like structures are common in mammals and many plants, they are challenging to detect in Arabidopsis thaliana. Here, we demonstrate that Arabidopsis PDS5 proteins play a negative role in TAD-like domain formation. Through Hi-C analysis, we show that mutations in PDS5 genes lead to the widespread...
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