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Decreased mitochondrial translation confers 3,3'-Diindolylmethane resistance to Schizosaccharomyces pombe.

Biochemical and biophysical research communications - 3 Dec 2024

Wang Kaiyu, Nagai Hideto, Rajib Samiul Alam, Satou Yorifumi, Ueno Masaru

Abstract excerpt

3,3'-Diindolylmethane (DIM), a compound derived from natural fruits and vegetables, is widely recognized for its anti-cancer activity. However, its action mechanisms remain ambiguous. In this study, to study the molecular mechanism of 3,3'-Diindolylmethane, we identified a novel mutation in the gene of mitochondrial translation elongation factor EF-Ts (tsf1+), a key factor in mitochondrial protein translation,...

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PMID: 39461006
DOI: 10.1016/j.bbrc.2024.150864

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