Article
Abnormal Vascular Phenotypes Associated with the Timing of Interruption of Retinal Vascular Development in Rats.
Biological & pharmaceutical bulletin - 1 Jan 2020
Kondo Ryo, Nakano Ayuki, Asano Daiki, Morita Akane, Arima Shiho, Mori Asami, Sakamoto Kenji, Nagamitsu Tohru, Nakahara Tsutomu
Abstract excerpt
Pathological angiogenesis is a leading cause of blindness in several retinal diseases. The key driving factor inducing pathological angiogenesis is the pronounced hypoxia leading to a marked, increased production of vascular endothelial growth factor (VEGF). The aim of this study was to determine whether the abnormal vascular growth occurs in a manner dependent on the degree of the vascular defects. Vascular...
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