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Calorie restriction modulates mitochondrial dynamics and autophagy in leukocytes of patients with obesity

22 Oct 2024

Abstract excerpt

Although it is established that caloric restriction offers metabolic and clinical benefits, the molecular mechanisms underlying these effects remain unclear. Thus, this study aimed to investigate whether caloric restriction can modulate mitochondrial function and remodeling and stimulate autophagic flux in the PBMCs of patients with obesity. This was an interventional study of 38 obese subjects (BMI >35 kg/m 2 )...

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PMID: 39447993
DOI: 10.1016/j.freeradbiomed.2024.10.295

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