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SARS-CoV-2 NSP6 reduces autophagosome size and affects viral replication via sigma-1 receptor

24 Oct 2024

Abstract excerpt

Autophagy is a cellular self-defense mechanism by which cells can kill invading pathogenic microorganisms and increase the presentation of components of pathogens as antigens. Contrarily, pathogens can utilize autophagy to enhance their own replication. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) NSP6 can interact with ATPase proton pump component to inhibit lysosomal acidification, which was...

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PMID: 39445785
DOI: 10.1128/jvi.00754-24

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