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The role of SARS-CoV-2 ORF7a in autophagy flux disruption: implications for viral infection and pathogenesis

15 Feb 2024

Abstract excerpt

Although alterations in the autophagy-lysosome pathway have been observed in the SARS-CoV-2 infection and invasion process since the outbreak of the coronavirus disease in 2019, the in-depth mechanism of autophagic and lysosomal reprogramming by SARS-CoV-2 has yet to be well identified. Our recent study unveiled a pivotal role played by the open reading frame 7a (ORF7a) protein in the SARS-CoV-2 genome,...

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PMID: 38361390
DOI: 10.1080/15548627.2024.2312787

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