Article
Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 genome modification in Drosophila.
Insect biochemistry and molecular biology - 1 Aug 2017
Douris Vassilis, Papapostolou Kyriaki-Maria, Ilias Aris, Roditakis Emmanuel, Kounadi Styliani, Riga Maria, Nauen Ralf, Vontas John
Abstract excerpt
Diamide insecticides are used widely against lepidopteran pests, acting as potent activators of insect Ryanodine Receptors (RyRs) and thus inducing muscle contraction and eventually death. However, resistant phenotypes have recently evolved in the field, associated with the emergence of target site resistance mutations (G4946E/V and I4790M). We investigated the frequency of the mutations found in a resistant...
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