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NSUN5 as a Prognostic Biomarker Correlates with Malignant Phenotype and Therapeutic Target in Glioma.

Brain and behavior - 1 Jan 2026

Wenhao Ye, Huan Wu, Xiaoyun Zou, Yuanyuan Yang, Junlei Bi, Changqing Liu, Mengyi Zhao, Yuyuan Zhang, Jin Lu, Hebao Wen, Caiyun Ma

Abstract excerpt

BACKGROUND: NSUN5 is a conserved RNA methyltransferase whose oncogenic role has been demonstrated in various cancers. However, its function and prognostic value in gliomas remain unclear. METHODS: In this study, we systematically analyzed the expression and functional associations of NSUN5 in glioma using data from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) databases. A total of 117...

Topics

Glioma
Humans
Prognosis
Biomarkers, Tumor
Methyltransferases
Brain Neoplasms
Gene Expression Regulation, Neoplastic
Machine Learning
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 41555554
DOI: 10.1002/brb3.71211
PMCID: PMC12816160

Genes

NSUN5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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