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Multi-omics analysis reveals the interplay between pulmonary microbiome and host in immunocompromised patients with sepsis-induced acute lung injury

18 Oct 2024

Abstract excerpt

ABSTRACT The mechanisms behind the high inflammatory state and immunocompromise in severe sepsis remain unclear. While microbiota’s role in immune regulation is known, the impact of pulmonary microbiota on sepsis progression is not fully understood. This study aims to investigate pulmonary microbial characteristics in septic patients and their relationship with host immune-related genes and clinical features....

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PMID: 39422492
DOI: 10.1128/spectrum.01424-24

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