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Article

A Strong Candidate Gene for Nonsyndromic Intellectual Disability Phenotype: SGSM3.

Clinical genetics - 1 Feb 2025

Turkyilmaz Ayberk, Saglam Kubra Adanur, Yilmaz Mustafa, Cebi Alper Han

Abstract excerpt

SGSM proteins are small modulator proteins interacting with proteins in the RAS signaling pathway. Studies with mouse and human tissues indicated that SGSM genes were highly expressed in the brain and could be expressed at different levels at different stages of development in fetal and adult brain tissue. It was first reported by Birnbaum et al. that the SGSM3 gene might be associated with a Mendelian inherited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39390489
DOI: 10.1111/cge.14631
PMCID: PMC11725557

Genes

SGSM3

Variants

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